Is this project an undergraduate, graduate, or faculty project?
Graduate
Project Type
group
Campus
Daytona Beach
Authors' Class Standing
Sabrina Ehrenfort, Graduate student Riley Dienna, Graduate student Ben Kerns, Graduate student Hannah Lyons, Graduate student Rachel Phillips, Graduate student
Lead Presenter's Name
Sabrina Ehrenfort
Lead Presenter's College
DB College of Arts and Sciences
Faculty Mentor Name
Dr. Scott Ferguson
Abstract
Increased work of breathing (Wb) triggers the inspiratory muscle metaboreflex, which elevates systemic blood pressure in response to diaphragmatic fatigue. To counteract this, dietary nitrate could act as a source of nitric oxide, which is known to improve muscle power and efficiency (Jones et al., 2018). This study examines the hypothesis that acute nitrate supplementation would attenuate this response. Utilizing the KH2 device from PowerBreathe, 20 healthy participants (mean age: 21.1 ± 2.5 years; range: 18–30 years) underwent a resistive breathing task (RBT) for a total of three minutes at 60% of their maximal inspiratory pressure (MIP). All 20 participants completed both a preliminary session and two experimental trials using a counterbalanced, repeated-measures design. Participants received either Beet It nitrate supplementation or a Beet It Placebo two hours prior to their RBT, separated by at least a one-week washout time. Blood pressure was monitored continuously throughout the protocol using the Finapres Non-Invasive Blood Pressure (NIBP) device. This included a one-minute resting period, the 3-minute RBT, and a one-minute recovery phase. Parameters recorded via NIBP include mean arterial pressure (MAP), systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR). We hypothesize that Beet It nitrate supplementation will attenuate the pressor response, lowering MAP, SBP, and DBP, compared to a placebo, while heart rate will remain unaffected across both conditions. Results from this study will provide valuable insights into the potential for dietary nitrates to manage the cardiovascular strain associated with respiratory distress and patient populations with an increased Wb.
Did this research project receive funding support (Spark, SURF, Research Abroad, Student Internal Grants, Collaborative, Climbing, or Ignite Grants) from the Office of Undergraduate Research?
No
Included in
Dietetics and Clinical Nutrition Commons, Respiratory System Commons, Sports Sciences Commons
The Effects of Acute Dietary Nitrate Supplementation on the Inspiratory Muscle Metaboreflex in Young Healthy Adults
Increased work of breathing (Wb) triggers the inspiratory muscle metaboreflex, which elevates systemic blood pressure in response to diaphragmatic fatigue. To counteract this, dietary nitrate could act as a source of nitric oxide, which is known to improve muscle power and efficiency (Jones et al., 2018). This study examines the hypothesis that acute nitrate supplementation would attenuate this response. Utilizing the KH2 device from PowerBreathe, 20 healthy participants (mean age: 21.1 ± 2.5 years; range: 18–30 years) underwent a resistive breathing task (RBT) for a total of three minutes at 60% of their maximal inspiratory pressure (MIP). All 20 participants completed both a preliminary session and two experimental trials using a counterbalanced, repeated-measures design. Participants received either Beet It nitrate supplementation or a Beet It Placebo two hours prior to their RBT, separated by at least a one-week washout time. Blood pressure was monitored continuously throughout the protocol using the Finapres Non-Invasive Blood Pressure (NIBP) device. This included a one-minute resting period, the 3-minute RBT, and a one-minute recovery phase. Parameters recorded via NIBP include mean arterial pressure (MAP), systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR). We hypothesize that Beet It nitrate supplementation will attenuate the pressor response, lowering MAP, SBP, and DBP, compared to a placebo, while heart rate will remain unaffected across both conditions. Results from this study will provide valuable insights into the potential for dietary nitrates to manage the cardiovascular strain associated with respiratory distress and patient populations with an increased Wb.