This research combines two multi-billion-dollar industries, sports and aviation, to understand how one influences the other. Ankle sprain is the world's most common injury in sports played across the globe which requires air travel to compete. Literature pertaining to parameters that would affect ankle sprains on airplanes was researched. The result of exposure to these changing parameters on ankle sprains was analyzed. Limited space, temperature, posture, nutrition and sleep were the major disadvantages for ankle sprain recovery. Testing can be performed under a controlled environment to further understand the limits of airplane conditions on ankle sprains. Data from this experimentation could be used towards effective solutions in the future. However, changes can be made in the present to assist athletes with ankle sprains during air travel. Apart from inexpensive solutions such as considering seat selection for increased natural movement and maintaining a diet, there are more dedicated solutions. An airplane such as the NIKE Athlete's Plane has features aiding athletes in the prehab and rehabilitation phase solving many travel related disadvantages. These solutions could reduce risk of injury, support recovery and promote optimum athletic performance.