Prolong stay in space can have adverse side effects on human body. Various space flight stressors such as microgravity, isolation, confinement, radiation exposure and circadian shifts can impact the i..
Prolong stay in space can have adverse side effects on human body. Various space flight stressors such as microgravity, isolation, confinement, radiation exposure and circadian shifts can impact the immune system drastically. One of the immune markers, interleukin-6 (IL-6), is shown to be elevated in blood when undergone these stressors. The research aims to develop an electrochemical impedance sensor to detect various concentration of IL-6 in saline solution by using surface enhancement methods on gold-coated pyramids fabricated using two-photon polymerization lithography (2PP). The biomolecules are attached to the gold coated pyramids enhanced surface area and are excited with 520 nm laser. The change in surface characteristic due to the attachment of biomolecule and the excitation is measure through impedance analyzer. The range of concentrations of IL-6 to be detected through these methods are from 1 pg/ml to 1µg/ml.
