Miguel Bastos Dominic Sandell Zachary Young Carol Mitchell William Horspool Alesha Fleming
Embry-Riddle Aeronautical University Embry Riddle Aeronautical University
Finasteride has been used to treat male pattern baldness and benign prostate hyperplasia, and could potentially treat female pattern baldness and polycystic ovary syndrome. The effects that finasterid..
Finasteride has been used to treat male pattern baldness and benign prostate hyperplasia, and could potentially treat female pattern baldness and polycystic ovary syndrome. The effects that finasteride ingestion has on reproduction in female patients is still inconclusive. Using Drosophila melanogaster as a model, this study was designed to investigate the impact of finasteride on female fly reproduction and their offspring. The female flies in this study will be fed dosage equivalents of 0.5 mg, 1 mg, and 5 mg of finasteride, with a control group of females who consume no finasteride. The flies will be allowed to mate after consuming their respective dose of the drug and the viable offspring will be counted over the next three days. Additionally, viable male offspring will be allowed to mate with female flies to determine if they are impacted by the drug. This study predicts the results will indicate that finasteride will impact the reproductive ability of the females and their male offspring. We will support these results by using an RNA sequencer to investigate their genome. These results will further the database that could lead to determining if finasteride could be used to treat the disorders in human females.