Is this project an undergraduate, graduate, or faculty project?

Undergraduate

individual

Authors' Class Standing

Haleema Irfan, Junior

Lead Presenter's Name

Haleema Irfan

Faculty Mentor Name

Foram Madiyar

Abstract

The project seeks to establish the link between toll-like receptors (TLR) in the pathogenesis of inflammation and formulate a trihydroxy benzoic acid (THBA) analog as a potential drug formulation for inflammatory diseases.

We aim to develop a stable drug-polymer complex of THBA using pH-sensitive polymers that will target inflammation. Various analogs of THBA will be synthesized with nano-co-precipitation experimentation for optimization using a variety of polymers, solvents, and stabilizers to increase the solubility in aqueous conditions and determine the most effective combination. The particle size, drug loading, and dissolution profile under various pH are discussed with various polymers. The formulated complex is solid and will be studied for biochemical, genetic changes in the human tissues in the class II environment. The physiological and pharmacological effects will be studied in live mice in an animal facility. Together the results will aid conclusively deduce the role of TLRs in the causation of inflammation, and efficacy of the drug. In the long term, this may reveal TLRs as druggable targets and the trihydroxy benzoic acid polymer complexes as an inhibitor of the TLRs respectively.

Did this research project receive funding support (Spark or Ignite Grants) from the Office of Undergraduate Research?

Yes, Ignite Grant

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Trihydroxybenzoic Acid Analogs as a Potential Drug Formulation for Inflammatory Diseases

The project seeks to establish the link between toll-like receptors (TLR) in the pathogenesis of inflammation and formulate a trihydroxy benzoic acid (THBA) analog as a potential drug formulation for inflammatory diseases.

We aim to develop a stable drug-polymer complex of THBA using pH-sensitive polymers that will target inflammation. Various analogs of THBA will be synthesized with nano-co-precipitation experimentation for optimization using a variety of polymers, solvents, and stabilizers to increase the solubility in aqueous conditions and determine the most effective combination. The particle size, drug loading, and dissolution profile under various pH are discussed with various polymers. The formulated complex is solid and will be studied for biochemical, genetic changes in the human tissues in the class II environment. The physiological and pharmacological effects will be studied in live mice in an animal facility. Together the results will aid conclusively deduce the role of TLRs in the causation of inflammation, and efficacy of the drug. In the long term, this may reveal TLRs as druggable targets and the trihydroxy benzoic acid polymer complexes as an inhibitor of the TLRs respectively.