Amelia Hartnett Foram Madiyar John J. Verecka Amelia Grace Lake Hartnett Ph.D
Embry-Riddle Aeronautical University Embry- Riddle Aeronautical Univerisity Roseman University of Pharmaceutical Sciences
Key Words: Drug- Polymer Complex, Intestinal Inflammatory Diseases, Silymarin, Formulation The aim of the project is to explore the effect of a pH- sensitive drug- polymer complex on Intestinal Inflam..
Key Words: Drug- Polymer Complex, Intestinal Inflammatory Diseases, Silymarin, Formulation The aim of the project is to explore the effect of a pH- sensitive drug- polymer complex on Intestinal Inflammatory Bowel Disease (IBD) and proctitis by demonstrating the link between toll-like receptors (TLR) in the pathogenesis of inflammation and formulate a Silymarin complex as a potential drug formulation. Inflammatory Bowel Disease (IBD) affects approximately 1.6 million Americans, with a growth of 12.5% since 2011. Proctitis is a condition where the lining of the rectum becomes inflamed; approximately 750,000 Americans live with this condition. Currently, all available pharmaceutical solutions have poor bioavailability for IBD and proctitis, and we anticipate the pH sensitive polymer will aid in overcoming this issue. We developed a stable drug-polymer complex of Silymarin using a combination of pH-sensitive polymers through nano-precipitation methods. This poster demonstrates the ideal combination of solvents, polymers, and stabilizers for the most effective combination for pH sensitive delivery. The characterization of the drug polymer complex was through Fourier transform Infrared Spectroscopy (FTIR), and concentration was measured utilizing Folin-Ciocalteu reagent using UV-visible spectroscopy. The other tests performed drug loading, compound size, and dissociation profile under different pH’s. For future tests, the complex will be surveyed for biochemical, and genetic changes in animal tissues to understand the role that TLRs play in the causation of inflammation.