Skin disease proves an issue of urgency, as they are the fourth most common cause of human disease, impacting nearly one-third of the global population. Due to the cost and complexity of topical produ..
Skin disease proves an issue of urgency, as they are the fourth most common cause of human disease, impacting nearly one-third of the global population. Due to the cost and complexity of topical products ranging from creams to assisted technology, an alternative solution for wound healing and skin lesion treatment is desired. Additive manufacturing has been used for various applications in healthcare including personalized prosthetics, implants, and models for surgical education. According to literature, the use of 3D printing as a means of development for personalized topical dosage forms and wound dressings reveals promising as it allows for use of materials with various physical and mechanical properties. Although this is the case, current 3D printed applications for wound healing dressings are generic regarding their dosage forms, and require personalization to provide individuals with an appropriate quantity in accordance with weight, genetics, age, and health conditions. The primary objective of this study is to resolve generic drug delivery systems through proving the broad applicability of 3D printing in the production of wound healing dressings. In this study, the active drug delivery of neomycin will be tested through three dressings of parallel, crosshatched, and 45 degree crosshatched patterns. The wound healing dressings will be tested through the use of thermally responsive and pH responsive polymers in an in vitro study to assess effectivity of the dressing under conditions similar to that of an inflamed wound site. The durability of the wound healing dressing will also be tested through the evaluation of the degradation of hydrogel through incubation and dialysis bag techniques.