Is this project an undergraduate, graduate, or faculty project?
Undergraduate
Project Type
group
Campus
Daytona Beach
Authors' Class Standing
Brian Davies, Junior Jonah Reed, Junior
Lead Presenter's Name
Reghan Schafer
Lead Presenter's College
DB College of Engineering
Faculty Mentor Name
Foram Madiyar
Abstract
The Magnetic Actuation Chamber System (MACS) is an innovative solution designed to enhance the cultivation of cells and tissues under simulated microgravity conditions using a 3D clinostat. By integrating a magnetic actuator with a microfluidic organ-on-chip platform, the system facilitates precise mechanical stimuli for tissue engineering and disease modeling. Key upgrades, including a pneumatic piston system, Raspberry Pi 4-based processing, and enhanced nutrient delivery through microfluidic pumps, significantly improve reliability, data collection, and adaptability. The system’s modular design ensures flexibility for future modifications. Initial results demonstrate the potential of MACS to replicate natural cellular environments, with plans to study heart and lung cell growth under simulated conditions. This research aims to explore cellular behavior in microgravity, with potential applications in cancer treatment and regenerative medicine. The MACS represents a critical advancement in biotechnological research, providing insights into cell growth mechanisms and supporting novel therapeutic discoveries. The SURF Grant was used for prototyping the system, and the Ignite Grant is being used for finalizing the project.
Did this research project receive funding support (Spark, SURF, Research Abroad, Student Internal Grants, Collaborative, Climbing, or Ignite Grants) from the Office of Undergraduate Research?
Yes, Ignite Grant
Magnetic Actuation Chamber System
The Magnetic Actuation Chamber System (MACS) is an innovative solution designed to enhance the cultivation of cells and tissues under simulated microgravity conditions using a 3D clinostat. By integrating a magnetic actuator with a microfluidic organ-on-chip platform, the system facilitates precise mechanical stimuli for tissue engineering and disease modeling. Key upgrades, including a pneumatic piston system, Raspberry Pi 4-based processing, and enhanced nutrient delivery through microfluidic pumps, significantly improve reliability, data collection, and adaptability. The system’s modular design ensures flexibility for future modifications. Initial results demonstrate the potential of MACS to replicate natural cellular environments, with plans to study heart and lung cell growth under simulated conditions. This research aims to explore cellular behavior in microgravity, with potential applications in cancer treatment and regenerative medicine. The MACS represents a critical advancement in biotechnological research, providing insights into cell growth mechanisms and supporting novel therapeutic discoveries. The SURF Grant was used for prototyping the system, and the Ignite Grant is being used for finalizing the project.