HIF-1 ACTIVATION AND INFLAMMATORY RESPONSES TO HYPOXIA

Authors

Shazreen shaharuddin, Department of Physiology, Faculty of Medicine and Health Defence, National Defence University of Malaysia, Kem Sungai Besi, 57000 Kuala Lumpur.Follow
Nik Mohd Afizan Nik Abd Rahman, Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor, Malaysia; Institute of Tropical Forestry and Forest Products, UniversitiPutra Malaysia, 43400 Serdang, Selangor, Malaysia.Follow
Mas Jaffri Masarudin, Institute of Tropical Forestry and Forest Products, UniversitiPutra Malaysia, Selangor, Malaysia; Nanomaterials Synthesis and Characterisation Laboratory, Institute of Nanoscience and Nanotechnology, UniversitiPutra Malaysia, 43400 Serdang, Selangor, Malaysia.Follow
Mohammedarfat N Alamassi, Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, SelangorFollow

Abstract

Acute hypoxia is a significant physiological danger during high-altitude flying and military aircraft missions. The human brain requires a constant supply of oxygen to function properly, and is susceptible to settings with low availability of air oxygen. Hypoxia can influence inflammatory signalling, and both central and systemic responses can activate HIF pathway genes. HIFs are critical molecules that regulate inflammation andhypoxia, ensuring appropriate cell function and survival. Hypoxia is the condition in which insufficient oxygen reaches the body's tissues. It can be caused by a decrease in partial oxygen pressure (PO2) in the environment, problems with breathing and/or oxygen transport, or the inability of tissues to utilise oxygen. Different organs are hypoxic due to differences in tissue oxygen tensions, which are determined by differences in aerobic metabolism. Extremely hypoxic individuals have the most dramatic systemic and neurological adaptations to persistent hypoxia. In this review, we provide an overview of central and systemic responses to hypoxia and discuss the activation of HIF-1 pathway.

Acknowledgements

This research was funded by Asian office of aerospace research and development (AOARD) grant with number (FA2386-21-1-4007).

Scholarly Commons Citation

shaharuddin, S., Rahman, N., Masarudin, M., & Alamassi, M. (2023). HIF-1 ACTIVATION AND INFLAMMATORY RESPONSES TO HYPOXIA. International Journal of Aviation, Aeronautics, and Aerospace, 10(2). DOI: https://doi.org/10.58940/2374-6793.1798