group

Authors' Class Standing

Arka Das, Graduate student Dr. Ray Prather, Post doctoral scholar Kayla livingston, Sophomore Dr. Eduardo Divo, Faculty Dr. Alain Kassab, Faculty Dr. Michael Farias, Clinician Dr. William DeCampli, Clinician

Lead Presenter's Name

Arka Das

Faculty Mentor Name

Dr. Eduardo Divo

Abstract

Introduction: Hypoplastic Left Heart Syndrome (HLHS) is a Congenital Heart Disease (CHD) that leads to a single ventricle circulation (SV). The existing three-stage palliative operation leads to 50% survival rates. To reduce the morbidity and mortality rate associated with the procedure, an alternative technique called Hybrid Comprehensive Stage II (HCSII) featuring the inclusion of a stent and baffle in the left and right pulmonary arteries shown is proposed. The included stent included has the potential to become fractured as a result of oscillatory asymmetric external loads.

Materials and Methods: A dynamically-scaled mock flow loop (MFL) study of HCSII shows the effects of fluid pressure on the stent and baffle to infer long term complications validated with numerical simulations. The MFL includes a patient-specific 3D printed model of the reconstructed anatomy, incorporating an intra-pulmonary baffle graft and a stent. Through the inclusion of the digital video otoscope DE500, videos of the stent and baffle are captured and post-processed to determine baffle displacement during the systolic and diastolic phases. Stent deformation is quantified using Scanning Electron Microscope (SEM).Experimental results are cross-validated, using finite element analysis done in Abaqus.

Results and Discussion: The displacement of the baffle is tracked in three different locations throughout the cycles. Between peak systole to peak diastole, the computed baffle displacement for each tracked location, based on the processed image data, is 38, 4 and 6 pixels respectively.

Conclusions: For 10 cycles, the stent and the baffle deformations are small. Results indicate the left and right pulmonary flow remain unobstructed despite cyclic deformation of the baffle, hence the likelihood of patient death due to total pulmonary obstruction following stent collapse is low.

Did this research project receive funding support (Spark or Ignite Grants) from the Office of Undergraduate Research?

No

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Evaluation of Stent and Baffle Deformation in Hybrid Comprehensive Stage II Procedure

Introduction: Hypoplastic Left Heart Syndrome (HLHS) is a Congenital Heart Disease (CHD) that leads to a single ventricle circulation (SV). The existing three-stage palliative operation leads to 50% survival rates. To reduce the morbidity and mortality rate associated with the procedure, an alternative technique called Hybrid Comprehensive Stage II (HCSII) featuring the inclusion of a stent and baffle in the left and right pulmonary arteries shown is proposed. The included stent included has the potential to become fractured as a result of oscillatory asymmetric external loads.

Materials and Methods: A dynamically-scaled mock flow loop (MFL) study of HCSII shows the effects of fluid pressure on the stent and baffle to infer long term complications validated with numerical simulations. The MFL includes a patient-specific 3D printed model of the reconstructed anatomy, incorporating an intra-pulmonary baffle graft and a stent. Through the inclusion of the digital video otoscope DE500, videos of the stent and baffle are captured and post-processed to determine baffle displacement during the systolic and diastolic phases. Stent deformation is quantified using Scanning Electron Microscope (SEM).Experimental results are cross-validated, using finite element analysis done in Abaqus.

Results and Discussion: The displacement of the baffle is tracked in three different locations throughout the cycles. Between peak systole to peak diastole, the computed baffle displacement for each tracked location, based on the processed image data, is 38, 4 and 6 pixels respectively.

Conclusions: For 10 cycles, the stent and the baffle deformations are small. Results indicate the left and right pulmonary flow remain unobstructed despite cyclic deformation of the baffle, hence the likelihood of patient death due to total pulmonary obstruction following stent collapse is low.