Is this project an undergraduate, graduate, or faculty project?
Graduate
Project Type
individual
Campus
Daytona Beach
Authors' Class Standing
First Year Graduate Student
Lead Presenter's Name
Sahil Ghate
Lead Presenter's College
DB College of Arts and Sciences
Faculty Mentor Name
Foram Madiyar
Abstract
Prolong stay in space can have adverse side effects on human body. Various space flight stressors such as microgravity, isolation, confinement, radiation exposure and circadian shifts can impact the immune system drastically. One of the immune markers, interleukin-6 (IL-6), is shown to be elevated in blood when undergone these stressors. The research aims to develop an electrochemical impedance sensor to detect various concentration of IL-6 in saline solution by using surface enhancement methods on gold-coated pyramids fabricated using two-photon polymerization lithography (2PP). The biomolecules are attached to the gold coated pyramids enhanced surface area and are excited with 520 nm laser. The change in surface characteristic due to the attachment of biomolecule and the excitation is measure through impedance analyzer. The range of concentrations of IL-6 to be detected through these methods are from 1 pg/ml to 1µg/ml.
Did this research project receive funding support (Spark, SURF, Research Abroad, Student Internal Grants, Collaborative, Climbing, or Ignite Grants) from the Office of Undergraduate Research?
Yes, Student Internal Grants
Inflammation Monitoring by Two photon Polymerized Enhanced Surface Sensors
Prolong stay in space can have adverse side effects on human body. Various space flight stressors such as microgravity, isolation, confinement, radiation exposure and circadian shifts can impact the immune system drastically. One of the immune markers, interleukin-6 (IL-6), is shown to be elevated in blood when undergone these stressors. The research aims to develop an electrochemical impedance sensor to detect various concentration of IL-6 in saline solution by using surface enhancement methods on gold-coated pyramids fabricated using two-photon polymerization lithography (2PP). The biomolecules are attached to the gold coated pyramids enhanced surface area and are excited with 520 nm laser. The change in surface characteristic due to the attachment of biomolecule and the excitation is measure through impedance analyzer. The range of concentrations of IL-6 to be detected through these methods are from 1 pg/ml to 1µg/ml.