Is this project an undergraduate, graduate, or faculty project?
Graduate
group
What campus are you from?
Daytona Beach
Authors' Class Standing
Miguel Bastos, Senior Carol Mitchell, Graduate Student Dominic Sandell, Sophomore Zachary Young, Senior William Horspool, Graduate Student
Lead Presenter's Name
Miguel Bastos
Faculty Mentor Name
Alesha Fleming
Abstract
Finasteride has been used to treat male pattern baldness and benign prostate hyperplasia, and could potentially treat female pattern baldness and polycystic ovary syndrome. The effects that finasteride ingestion has on reproduction in female patients is still inconclusive. Using Drosophila melanogaster as a model, this study was designed to investigate the impact of finasteride on female fly reproduction and their offspring. The female flies in this study will be fed dosage equivalents of 0.5 mg, 1 mg, and 5 mg of finasteride, with a control group of females who consume no finasteride. The flies will be allowed to mate after consuming their respective dose of the drug and the viable offspring will be counted over the next three days. Additionally, viable male offspring will be allowed to mate with female flies to determine if they are impacted by the drug. This study predicts the results will indicate that finasteride will impact the reproductive ability of the females and their male offspring. We will support these results by using an RNA sequencer to investigate their genome. These results will further the database that could lead to determining if finasteride could be used to treat the disorders in human females.
Did this research project receive funding support from the Office of Undergraduate Research.
Yes, Spark Grant
The effects of Finasteride on parity in female drosophila melanogaster
Finasteride has been used to treat male pattern baldness and benign prostate hyperplasia, and could potentially treat female pattern baldness and polycystic ovary syndrome. The effects that finasteride ingestion has on reproduction in female patients is still inconclusive. Using Drosophila melanogaster as a model, this study was designed to investigate the impact of finasteride on female fly reproduction and their offspring. The female flies in this study will be fed dosage equivalents of 0.5 mg, 1 mg, and 5 mg of finasteride, with a control group of females who consume no finasteride. The flies will be allowed to mate after consuming their respective dose of the drug and the viable offspring will be counted over the next three days. Additionally, viable male offspring will be allowed to mate with female flies to determine if they are impacted by the drug. This study predicts the results will indicate that finasteride will impact the reproductive ability of the females and their male offspring. We will support these results by using an RNA sequencer to investigate their genome. These results will further the database that could lead to determining if finasteride could be used to treat the disorders in human females.