individual
What campus are you from?
Daytona Beach
Authors' Class Standing
Rahela Dolha, Senior
Lead Presenter's Name
Rahela Dolha
Faculty Mentor Name
Dr. Mubarak Mujawar
Abstract
The development and use of point-of-care (POC) biosensors is more widespread than ever. Their popularity provides opportunity for portable and cost-effective medical testing anywhere at any time. Results are rapid and continuous while maintaining a user-friendly interface. Unfortunately, their small size decreases sensor amplification and sensitivity/limit of detection, resulting in inaccurate measurements. In order to increase sensor sensitivity and amplification, this study optimizes the synthesis of an electrosprayed nanofiber matrix whose high surface area increases an inflammation sensor’s sensitivity and signal amplification. The nanofiber will be made of biodegradable materials such as chitosan and nanocellulose, and will contain PVA which is selectively biodegradable, allowing for the sensor to be ethically disposed after use. This organic matrix, when used as the base for the proposed sensor, creates a larger electrochemically reactive surface (as compared to a flat glass base) which is proven to increase the amplification and sensitivity of biosensors. In our experiments, the electrosprayed material created a significant increase in cyclic voltammetry amplification and electrochemically reactive surface area. By solving this issue, POC biosensors can become a more accessible and realistic option for groups and communities that lack access to medical testing facilities for social, economic, geographically, or physical reasons.
Did this research project receive funding support from the Office of Undergraduate Research.
No
Synthesis of Biodegradable Nanofibers for the Increase of Biosensor Sensitivity
The development and use of point-of-care (POC) biosensors is more widespread than ever. Their popularity provides opportunity for portable and cost-effective medical testing anywhere at any time. Results are rapid and continuous while maintaining a user-friendly interface. Unfortunately, their small size decreases sensor amplification and sensitivity/limit of detection, resulting in inaccurate measurements. In order to increase sensor sensitivity and amplification, this study optimizes the synthesis of an electrosprayed nanofiber matrix whose high surface area increases an inflammation sensor’s sensitivity and signal amplification. The nanofiber will be made of biodegradable materials such as chitosan and nanocellulose, and will contain PVA which is selectively biodegradable, allowing for the sensor to be ethically disposed after use. This organic matrix, when used as the base for the proposed sensor, creates a larger electrochemically reactive surface (as compared to a flat glass base) which is proven to increase the amplification and sensitivity of biosensors. In our experiments, the electrosprayed material created a significant increase in cyclic voltammetry amplification and electrochemically reactive surface area. By solving this issue, POC biosensors can become a more accessible and realistic option for groups and communities that lack access to medical testing facilities for social, economic, geographically, or physical reasons.