Submitting Campus
Daytona Beach
Department
Human Factors and Behavioral Neurobiology
Document Type
Article
Publication/Presentation Date
10-19-2016
Abstract/Description
CD8 T cells are crucial components of immunity and play a vital role in recovery from West Nile virus (WNV) infection. Here, we identify a previously unrecognized function of interleukin-17A (IL-17A) in inducing cytotoxic-mediator gene expression and promoting CD8 T cell cytotoxicity against WNV infection in mice. We find that IL-17A-deficient (Il17a/) mice are more susceptible to WNV infection and develop a higher viral burden than wild-type (WT) mice. Interestingly, the CD8 T cells isolated from Il17a/ mice are less cytotoxic and express lower levels of cytotoxic-mediator genes, which can be restored by supplying recombinant IL-17A in vitro and in vivo. Importantly, treatment of WNV-infected mice with recombinant IL17A, as late as day 6 post infection, significantly reduces the viral burden and increases survival, suggesting a therapeutic potential for IL-17A. In conclusion, we report a novel function of IL-17A in promoting CD8 T cell cytotoxicity, which may have broad implications in other microbial infections and cancers.
Publication Title
Journal of Virology
DOI
https://doi.org/10.1128/JVI.01529-16
Publisher
American Society for Microbiology
Scholarly Commons Citation
Paul, A. M., Acharya, D., Wang, P., Dai, J., & Gate, D. (2016). Interleukin-17A Promotes CD8 T Cell Cytotoxicity to Facilitate West Nile Virus Clearance. Journal of Virology, 91(1). https://doi.org/10.1128/JVI.01529-16
Included in
Behavioral Neurobiology Commons, Biological Phenomena, Cell Phenomena, and Immunity Commons, Immunity Commons, Neurology Commons, Neurosciences Commons, Virology Commons
Additional Information
Dr. Paul was not affiliated with Embry-Riddle Aeronautical University at the time this paper was published.